| 存储条件 |
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| Product Name | Phospholipase C gamma 1 [SN06-10] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | 1 phosphatidyl D myo inositol 4 5 bisphosphate antibody 1 phosphatidylinositol 4 5 bisphosphate phosphodiesterase gamma 1 antibody 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 antibody Inositoltrisphosphohydrolase antibody Monophosphatidylinositol phosphodiesterase antibody NCKAP3 antibody Phosphatidylinositol phospholipase C antibody Phosphoinositidase C antibody Phosphoinositide phospholipase C antibody Phosphoinositide phospholipase C-gamma-1 antibody Phospholipase C 148 antibody Phospholipase C gamma 1 antibody Phospholipase C-gamma-1 antibody Phospholipase C-II antibody PLC gamma 1 antibody PLC II antibody PLC-148 antibody PLC-gamma-1 antibody PLC-II antibody PLC1 antibody PLC148 antibody Plcg1 antibody PLCG1_HUMAN antibody PLCgamma1 antibody |
| Product description | Phosphoinositide-specific phospholipase C (PLC) plays a crucial role in the initiation of receptor mediated signal transduction through the generation of the two second messengers, inositol 1,4,5-triphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. There are many mammalian PLC isozymes, including PLC β1, PLC β2, PLC β3, PLC β4, PLC γ1, PLC γ2, PLC δ1, PLC δ2 and PLCε. PLC γ1 is widely distributed in bronchiolar epithelium, type I and II pneumocytes and fibroblasts of the interstitial tissue. Actin-regulatory protein Villin is tyrosine phosphorylated and associates with PLC γ1 in the brush border of intestinal epithelial cells. Villin regulates PLC γ1 activity by modifying its own ability to bind phosphatidylinositol 4,5-biphosphate. PLC γ1 binds Integrin α1/β1 and modulates Integrin α1/β-specific adhesion. PLC γ1 and Ca2+ play a direct role in VEGF-regulated endothelial growth, however this signaling pathway is not linked to FGF-mediated effects in primary endothelial cells. PLC γ1 is rapidly activated in response to growth factor stimulation and plays an important role in regulating cell proliferation and differentiation. It may also have a protective function during cellular response to oxidative stress. |
| Immunogen | recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Recombinant rabbit |
| Tested Applications | WBICCIP |
| WB:1:1,000 ICC:1:50-1:200 | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Unpurified |
| Alternative Names | 1 phosphatidyl D myo inositol 4 5 bisphosphate antibody 1 phosphatidylinositol 4 5 bisphosphate phosphodiesterase gamma 1 antibody 1-phosphatidylinositol-4 5-bisphosphate phosphodiesterase gamma-1 antibody Inositoltrisphosphohydrolase antibody Monophosphatidylinositol phosphodiesterase antibody NCKAP3 antibody Phosphatidylinositol phospholipase C antibody Phosphoinositidase C antibody Phosphoinositide phospholipase C antibody Phosphoinositide phospholipase C-gamma-1 antibody Phospholipase C 148 antibody Phospholipase C gamma 1 antibody Phospholipase C-gamma-1 antibody Phospholipase C-II antibody PLC gamma 1 antibody PLC II antibody PLC-148 antibody PLC-gamma-1 antibody PLC-II antibody PLC1 antibody PLC148 antibody Plcg1 antibody PLCG1_HUMAN antibody PLCgamma1 antibody |
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| Molecular Weight(MW) | 149 kDa |
| Cellular Localization | Cell projection. |
Application
Fig1: ICC staining PLC γ1 in SHG-44 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Application
Fig2: ICC staining PLC γ1 in MCF-7 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.| Positive Control | SHG-44, MCF-7. |
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| Application Notes | WB:1:1,000 ICC:1:50-1:200 |
| Form | Liquid |
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| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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