| 存储条件 |
|---|
| Product Name | POMC [B5-D2] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | ACTH antibody Adrenocorticotropic hormone antibody Adrenocorticotropin antibody alpha melanocyte stimulating hormone antibody Alpha MSH antibody Alpha-MSH antibody beta endorphin antibody Beta LPH antibody beta melanocyte stimulating hormone antibody Beta MSH antibody Beta-LPH antibody Beta-MSH antibody CLIP antibody COLI_HUMAN antibody Corticotropin like intermediary peptide antibody Corticotropin lipotropin antibody Corticotropin-lipotropin antibody Gamma MSH antibody Gamma-LPH antibody Gamma-MSH antibody Lipotropin beta antibody Lipotropin gamma antibody LPH antibody Melanotropin alpha antibody Melanotropin antibody Melanotropin beta antibody Melanotropin gamma antibody met enkephalin antibody Met-enkephalin antibody MSH antibody NPP antibody POC antibody POMC antibody pro ACTH endorphin antibody Proopiomelanocortin antibody Proopiomelanocortin preproprotein antibody |
| Product description | POMC (pro-opiomelanocortin), also known as corticotropin-lipotropin, is a 267 amino acid polypeptide hormone precursor that goes through extensive, tissue-specific post-translational processing by prohormone convertases. POMC is cleaved into ten hormone chains named NPP, γ-MSH, ACTH, α-MSH, CLIP (corticotropin-like intermediary peptide), Lipotropin β, Lipotropin γ, β-MSH, β endorphin and Met-enkephalin. Defects in the gene that encodes POMC are the cause of POMC deficiency, which is characterized by red hair and adrenal insufficiency. Mutations in the POMC gene have also been linked to susceptibility to obesity. ACTH, also known as corticotropin, is a 39 amino acid active peptide that stimulates the secretion of cortisol by the adrenal gland. CLIP is a 21 amino acid neuropeptide secreted by corticotrope cells of adenohypophysis. |
| Immunogen | Recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Host Species | Mouse |
| Tested Applications | WBICC |
| WB:1:500-1:2,000 ICC:1:50-1:200 | |
| Species Reactivity | Human |
| Concentration | 2mg/ml |
| Purification | Unpurified |
| Alternative Names | ACTH antibody Adrenocorticotropic hormone antibody Adrenocorticotropin antibody alpha melanocyte stimulating hormone antibody Alpha MSH antibody Alpha-MSH antibody beta endorphin antibody Beta LPH antibody beta melanocyte stimulating hormone antibody Beta MSH antibody Beta-LPH antibody Beta-MSH antibody CLIP antibody COLI_HUMAN antibody Corticotropin like intermediary peptide antibody Corticotropin lipotropin antibody Corticotropin-lipotropin antibody Gamma MSH antibody Gamma-LPH antibody Gamma-MSH antibody Lipotropin beta antibody Lipotropin gamma antibody LPH antibody Melanotropin alpha antibody Melanotropin antibody Melanotropin beta antibody Melanotropin gamma antibody met enkephalin antibody Met-enkephalin antibody MSH antibody NPP antibody POC antibody POMC antibody pro ACTH endorphin antibody Proopiomelanocortin antibody Proopiomelanocortin preproprotein antibody |
|---|---|
| Molecular Weight(MW) | 29 kDa |
| Cellular Localization | Secreted |
| SwissProt ID | P01189 |
|---|
Application
Fig1: Western blot analysis of POMC on human POMC recombinant protein using anti-POMC antibody at 1/1,000 dilution.
Application
Fig2: Western blot analysis of POMC on HEK293 (1) and POMC-hIgGFc transfected HEK293 (2) cell lysate using anti-Rab3a antibody at 1/1,000 dilution.
Application
Fig3:ICC staining POMC (green) and Actin filaments (red) in Hela cells. The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.| Positive Control | Human POMC recombinant protein, POMC-hIgGFc transfected HEK293 cell lysate, Hela. |
|---|---|
| Application Notes | WB:1:500-1:2,000 ICC:1:50-1:200 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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