60S acidic ribosomal protein P1 antibody AA409079 antibody AI325195 antibody AU020965 antibody ik:tdsubc_2g1 antibody M(2)21C antibody MGC137236 antibody OTTHUMP00000004008 antibody p32 antibody p34 antibody RCJMB04_6d17 replication protein A2, 32kDa antibody REPA2 antibody Replication factor A protein 2 antibody Replication protein A 32 kDa subunit antibody Replication protein A 32kDa subunit antibody Replication protein A 34 kDa subunit antibody Replication protein A antibody Replication Protein A2 (32kDa) antibody Replication protein A2 antibody Replication protein A2, 32kDa antibody RF-A protein 2 antibody Rf-A2 antibody RFA antibody RFA2_HUMAN antibody RP-A p32 antibody RP-A p34 antibody RP21C antibody RPA 2 antibody RPA 32 antibody RPA antibody Rpa2 antibody RPA32 antibody RPA34 antibody RpLP1 antibody RpP2 antibody xx:tdsubc_2g1 antibody zgc:109822 antibody
Product description
The single-stranded-DNA-binding proteins (SSBs) are essential for DNA function in prokaryotic and eukaryotic cells, mitochondria, phages and viruses. Replication protein A (RPA), a highly conserved eukaryotic protein, is a heterotrimeric SSB. RPA plays an important role in DNA replication, recombination and repair. The binding of human RPA (hRPA) to DNA involves molecular polarity in which initial hRPA binding occurs on the 5' side of a ssDNA substrate and then extends in the 3' direction to create a stably bound hRPA. RPA is a major damage-recognition protein involved in the early stages of nucleotide excision repair. It can also play a role in telomere maintenance. The C-terminus of RPA 32 can specfically intereact with the DNA repair enzyme UNG2 and repair factors XPA and Rad52, each of which functions in a different repair pathway. In addition, RPA 32 binds specifically to the SH2 domain of Stat3 in vivo, and overexpression of RPA 32 corresponds to the augmented growth factor-stimulated tyrosine phosphorylation and transcription activities of Stat3.
Immunogen
recombinant protein
Modification
p-T21
Key Feature
Clonality
Monoclonal
Isotype
IgG
Host Species
Recombinant rabbit
Tested Applications
WBIP
WB:1:1,000
Species Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Unpurified
Target Information
Alternative Names
60S acidic ribosomal protein P1 antibody AA409079 antibody AI325195 antibody AU020965 antibody ik:tdsubc_2g1 antibody M(2)21C antibody MGC137236 antibody OTTHUMP00000004008 antibody p32 antibody p34 antibody RCJMB04_6d17 replication protein A2 32kDa antibody REPA2 antibody Replication factor A protein 2 antibody Replication protein A 32 kDa subunit antibody Replication protein A 32kDa subunit antibody Replication protein A 34 kDa subunit antibody Replication protein A antibody Replication Protein A2 (32kDa) antibody Replication protein A2 antibody Replication protein A2 32kDa antibody RF-A protein 2 antibody Rf-A2 antibody RFA antibody RFA2_HUMAN antibody RP-A p32 antibody RP-A p34 antibody RP21C antibody RPA 2 antibody RPA 32 antibody RPA antibody Rpa2 antibody RPA32 antibody RPA34 antibody RpLP1 antibody RpP2 antibody xx:tdsubc_2g1 antibody zgc:109822 antibody
