| 存储条件 |
|---|
| Product Name | GARS [SC0651] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | AP 4 A synthetase antibody Charcot Marie Tooth neuropathy 2D antibody Charcot Marie Tooth neuropathy neuronal type D antibody CMT2D antibody Diadenosine tetraphosphate synthetase antibody DSMAV antibody EC 6.1.1.14 antibody Glycine tRNA ligase antibody Glycyl tRNA synthetase antibody GlyRS antibody HMN5 antibody SMAD1 antibody |
| Product description | The fidelity of protein synthesis requires efficient discrimination of amino acid substrates by aminoacyl-tRNA synthetases. Proteins belonging to this family function to catalyze the aminoacylation of tRNAs by their corresponding amino acids, thus linking amino acids with tRNA-contained nucleotide triplets. GlyRS (Glycyl-tRNA synthetase), also known as Glycine-tRNA ligase, is a 739 amino acid class II synthetase that is widely expressed, including in the brain and spinal cord. Defects in the gene encoding GlyRS is the cause of Charcot-Marie-Tooth disease type 2D (CMT2D), which is an autosomal dominant inherited disease characterized by severe weakness, atrophy and absence of deep tendon reflexes in the upper extremities. Defects in the GlyRS gene is also the cause of distal hereditary muscular neuropathy type V (HMN5), a disease similar to CMT2D, though the distal sensory involvement is less severe in HMN5 patients. |
| Immunogen | recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Recombinant rabbit |
| Tested Applications | WBIHC |
| WB:1:1,000-1:2,000 IHC:1:50-1:200 | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Alternative Names | AP 4 A synthetase antibody Charcot Marie Tooth neuropathy 2D antibody Charcot Marie Tooth neuropathy neuronal type D antibody CMT2D antibody Diadenosine tetraphosphate synthetase antibody DSMAV antibody EC 6.1.1.14 antibody Glycine tRNA ligase antibody Glycyl tRNA synthetase antibody GlyRS antibody HMN5 antibody SMAD1 antibody |
|---|---|
| Molecular Weight(MW) | 75 kDa |
| Cellular Localization | Cytoplasm, Mitochondrion, Cell projection. |
Application
Fig1: Western blot analysis of GARS on Raji cells lysates using anti-GARS antibody at 1/1,000 dilution.
Application
Fig2: Immunohistochemical analysis of paraffin-embedded mouse colon tissue using anti-GARS antibody. Counter stained with hematoxylin.
Application
Fig3: Immunohistochemical analysis of paraffin-embedded mouse heart tissue using anti-GARS antibody. Counter stained with hematoxylin.| Positive Control | Raji, mouse colon tissue, mouse heart tissue. |
|---|---|
| Application Notes | WB:1:1,000-1:2,000 IHC:1:50-1:200 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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