MGF antibody Signal transducer and activator of transcription 5A antibody Signal Transducer and Activator of Transcription 5B antibody STA5A_HUMAN antibody STAT 5A antibody STAT 5B antibody STAT5 antibody STAT5A antibody STAT5B antibody Transcription factor STAT5A antibody Transcription factor STAT5B antibody
Product description
Stat5 (Signal Transducers and Activators of Transcription 5) is important in regulating T cell functions involving the receptors for Interleukin-2 (IL-2). IL-2 stimulates the rapid phosphorylation of both serine and tyrosine residues of Stat5a and Stat5b in human T lymphocytes and in several IL-2-responsive lymphocytic cell lines. IL-2 differentially induces serine phosphorylation of Stat5a and Stat5b on Ser726 and Ser731, respectively. Stat5b is preferentially phosphorylated and displays more protracted serine phosphorylation kinetics than Stat5a. Both the acid-rich region and the COOH terminus of IL-2Rb can independently mediate IL-2-induced Stat 5a/b serine phosphorylation, suggesting that Stat5a/b serine phosphorylation occurs at a postreceptor level. Stat5a is phosphorylated on Tyr694 in a prolactin-sensitive manner, whereas serine phosphorylation is constitutive. Activation of Stat5 by IL-2 may help govern the biological effects of IL-2 during the immune response.
Immunogen
recombinant protein
Modification
p-Y694
Key Feature
Clonality
Monoclonal
Isotype
IgG
Host Species
Recombinant rabbit
Tested Applications
WBIHC
WB:1:1,000-1:2,000 IHC:1:50-1:200
Species Reactivity
HumanMouse
Concentration
1mg/ml
Purification
Unpurified
Target Information
Alternative Names
MGF antibody Signal transducer and activator of transcription 5A antibody Signal Transducer and Activator of Transcription 5B antibody STA5A_HUMAN antibody STAT 5A antibody STAT 5B antibody STAT5 antibody STAT5A antibody STAT5B antibody Transcription factor STAT5A antibody Transcription factor STAT5B antibody
