| 存储条件 |
|---|
| Product Name | Islet 1 [SC05-64] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Insulin gene enhancer protein ISL 1 antibody Insulin gene enhancer protein ISL-1 antibody Insulin related protein antibody ISL 1 antibody ISL LIM homeobox 1 antibody ISL1 antibody ISL1 transcription factor LIM homeodomain antibody ISL1 transcription factor, LIM/homeodomain (islet 1) antibody ISL1 transcription factor, LIM/homeodomain antibody ISL1_HUMAN antibody Islet-1 antibody Islet1 antibody |
| Product description | Islet-1 (ISL1 transcription factor, LIM/homeodomain) and Islet-2 (ISL2 transcription factor, LIM/homeodomain) contain amino-terminal LIM domains and a carboxy-terminal homeodomain and both influence developmental events. Islet-1 influences embryogenesis of the pancreatic islets of Langerhans and neural tube motor neuron differentiation. In developing mouse teeth, Islet-1 mediates patterning of dentition as an activator of Bmp4 expression in incisor (distal) areas of the stomatodeal epithelium. Islet-1 expression defines cardiac progenitor cell populations and is required for normal cardiac development and asymmetry. Islet-2 activity in newly generated motor neurons permits the diversification of visceral and somatic motor neuron subtypes in the developing spinal cord. Murine Islet-2 specifies retinal ganglion cell (RGC) laterality by repressing an ipsilateral pathfinding program unique to the ventral-temporal crescent (VTC) of RGCs in a Zic2- and EphB1-dependent manner. |
| Immunogen | recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Recombinant rabbit |
| Tested Applications | WBICC/IFIP |
| WB:1:1,000 ICC:1:50-1:200 | |
| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml |
| Alternative Names | Insulin gene enhancer protein ISL 1 antibody Insulin gene enhancer protein ISL-1 antibody Insulin related protein antibody ISL 1 antibody ISL LIM homeobox 1 antibody ISL1 antibody ISL1 transcription factor LIM homeodomain antibody ISL1 transcription factor LIM/homeodomain (islet 1) antibody ISL1 transcription factor LIM/homeodomain antibody ISL1_HUMAN antibody Islet-1 antibody Islet1 antibody |
|---|---|
| Molecular Weight(MW) | 39 kDa |
| Cellular Localization | Nucleus. |
Application
Fig1: Western blot analysis of Islet 1 on MCF-7 cell lysates using anti-Islet 1 antibody at 1/1,000 dilution.
Application
Fig2: ICC staining Islet 1 in A549 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.| Positive Control | A549, MCF-7. |
|---|---|
| Application Notes | WB:1:1,000 ICC:1:50-1:200 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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