| 存储条件 |
|---|
| Product Name | Integrin alpha V [SC56-07] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | CD51 antibody Integrin alpha-V light chain antibody integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) antibody Integrin, alpha V antibody Integrin, beta 6 antibody ITAV_HUMAN antibody ITGAV antibody ITGB6 antibody Vitronectin receptor subunit alpha antibody |
| Product description | Integrins are heterodimers composed of noncovalently associated transmembrane a and b subunits. The 16 a and 8 b subunits heterodimerize to produce more than 20 different receptors. Most integrin receptors bind ligands that are components of the extracellular matrix, including Fibronectin, collagen and vitronectin. Certain integrins can also bind to soluble ligands, such as fibrinogen, or to counterreceptors on adjacent cells such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. Ligands serve to cross-link or cluster integrins by binding to adjacent integrin receptors; both receptor clustering and ligand occupancy are necessary for the activation of integrin-mediated responses. In addition to mediating cell adhesion and cytoskeletal organization, integrins function as signaling receptors. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis. |
| Immunogen | recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Recombinant rabbit |
| Tested Applications | WBFC |
| WB:1:1,000-1:2,000 FC:1:50-1:100 | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Alternative Names | CD51 antibody Integrin alpha-V light chain antibody integrin alpha V (vitronectin receptor alpha polypeptide antigen CD51) antibody Integrin alpha V antibody Integrin beta 6 antibody ITAV_HUMAN antibody ITGAV antibody ITGB6 antibody Vitronectin receptor subunit alpha antibody |
|---|---|
| Molecular Weight(MW) | 86/116 kDa |
| Cellular Localization | Membrane. |
Application
Fig1: Western blot analysis of Integrin alpha V+beta 6 on different lysates using anti-Integrin alpha V+beta 6 antibody at 1/1,000 dilution.Positive control:Lane 1: A549Lane 2: PC-12
Application
Fig2: Flow cytometric analysis of MCF-7 cells with Integrin alpha V antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody.| Positive Control | A549, PC-12. |
|---|---|
| Application Notes | WB:1:1,000-1:2,000 FC:1:50-1:100 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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