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| Product Name | HtrA2/Omi [ST54-05] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | High temperature requirement protein A2 antibody HTRA 2 antibody HtrA like serine protease antibody HtrA serine peptidase 2 antibody HtrA, E. coli, homolog of, 2 antibody HtrA2 antibody HTRA2_HUMAN antibody mitochondrial antibody Omi stress regulated endoprotease antibody Omi stress-regulated endoprotease antibody PARK 13 antibody PARK13 antibody Protease serine 25 antibody PRSS 25 antibody PRSS25 antibody Serine protease 25 antibody Serine protease HTRA2 antibody Serine protease HTRA2 mitochondrial antibody Serine protease htra2 mitochondrial precursor antibody Serine protease omi antibody Serine proteinase OMI antibody |
| Product description | The human homolog of the E. Coli htrA gene product, HtrA, is identified in osteoarthritic cartilage and is repressed in SV40-transformed fibroblast. The gene encoding HtrA protein is highly conserved among mammalian species and belongs to the serine protease family. The HtrA protein contains an IGF-binding domain and exhibits endoproteolytic activity, including autocatalytic cleavage. HtrA is a secreted protein that is expressed in heterologous systems. HtrA plays a role in the degradation of denatured proteins and cell growth regulation. Human HtrA2 (also designated Omi), a novel member of the HtrA serine protease family, is highly homologous to HtrA (also known as L56 and HtrA1). HtrA2 is a ubiquitously expressed nuclear protease that is capable of autoproteolysis. The HtrA2 protein exists as two polypeptides and as an alternatively spliced form called D-Omi, which is predominately expressed in the kidney, colon and thyroid. Due to a modified PDZ domain, D-Omi does not interact with the known partner of HtrA2, the Mxi2 protein. Like HtrA, HtrA2 is involved in the degradation aberrantly folded proteins during conditions of cellular stress, suggesting that it may possess a chaperone-like role under normal conditions. |
| Immunogen | recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Recombinant rabbit |
| Tested Applications | WBIHCIP |
| WB:1:1,000-1:2,000 IHC:1:50-1:200 | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Alternative Names | High temperature requirement protein A2 antibody HTRA 2 antibody HtrA like serine protease antibody HtrA serine peptidase 2 antibody HtrA E. coli homolog of 2 antibody HtrA2 antibody HTRA2_HUMAN antibody mitochondrial antibody Omi stress regulated endoprotease antibody Omi stress-regulated endoprotease antibody PARK 13 antibody PARK13 antibody Protease serine 25 antibody PRSS 25 antibody PRSS25 antibody Serine protease 25 antibody Serine protease HTRA2 antibody Serine protease HTRA2 mitochondrial antibody Serine protease htra2 mitochondrial precursor antibody Serine protease omi antibody Serine proteinase OMI antibody |
|---|---|
| Molecular Weight(MW) | 38 kDa |
| Cellular Localization | Mitochondrion intermembrane space, Mitochondrion membrane. |
Application
Fig1: Western blot analysis of HtrA2 on 293 cell lysates using anti-HtrA2 antibody at 1/1,000 dilution.
Application
Fig2: Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-HtrA2 antibody. Counter stained with hematoxylin.
Application
Fig3: Immunohistochemical analysis of paraffin-embedded human colon cancer tissue using anti-HtrA2 antibody. Counter stained with hematoxylin.
Application
Fig4: Immunohistochemical analysis of paraffin-embedded mouse liver tissue using anti-HtrA2 antibody. Counter stained with hematoxylin.| Positive Control | 293, human liver tissue, human colon cancer tissue, mouse liver tissue. |
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| Application Notes | WB:1:1,000-1:2,000 IHC:1:50-1:200 |
| Form | Liquid |
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| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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