| 存储条件 |
|---|
| Product Name | GRK2 [ST05-60] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | ADRBK1 antibody Adrenergic beta receptor kinase 1 antibody ARBK1_HUMAN antibody BARK antibody BARK1 antibody Beta adrenergic receptor kinase 1 antibody Beta ARK 1 antibody Beta ARK1 antibody Beta-adrenergic receptor kinase 1 antibody Beta-ARK-1 antibody FLJ16718 antibody G protein coupled receptor kinase 2 antibody G-protein coupled receptor kinase 2 antibody GRK2 antibody |
| Product description | Heterotrimeric G protein-mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the continued presence of the agonist. This phenomenon, referred to as agonist-mediated desensitization, involves phosphorylation of the receptor by two classes of enzymes. The first class is comprised of the second messenger-regulated kinases, such as c-AMP dependent protein kinase A and protein kinase C. The second class includes the G protein-coupled receptor kinases (GRKs). At least seven members of the GRK family have been identified. These include rhodopsin kinase (GRK 1), two forms of beta-adrenergic receptor kinase: GRK 2 (betaARK, betaARK1) and GRK 3 (betaARK2), IT-11 (GRK 4), GRK 5, GRK 6 and GRK 7. Phosphorylation of receptors by GRKs appears to be strictly dependent on the receptor being in its agonist-activated state. |
| Immunogen | recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Recombinant rabbit |
| Tested Applications | WBIHC |
| WB:1:1,000-1:2,000 IHC:1:50-1:200 | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Unpurified |
| Alternative Names | ADRBK1 antibody Adrenergic beta receptor kinase 1 antibody ARBK1_HUMAN antibody BARK antibody BARK1 antibody Beta adrenergic receptor kinase 1 antibody Beta ARK 1 antibody Beta ARK1 antibody Beta-adrenergic receptor kinase 1 antibody Beta-ARK-1 antibody FLJ16718 antibody G protein coupled receptor kinase 2 antibody G-protein coupled receptor kinase 2 antibody GRK2 antibody |
|---|---|
| Molecular Weight(MW) | 80 kDa |
| Cellular Localization | Cytoplasm, Cell membrane. |
Application
Fig1: Western blot analysis of GRK2 on Hela cell lysates using anti-GRK2 antibody at 1/1,000 dilution.
Application
Fig2 Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-GRK2 antibody. Counter stained with hematoxylin.
Application
Fig3 Immunohistochemical analysis of paraffin-embedded human spleen tissue using anti-GRK2 antibody. Counter stained with hematoxylin.
Application
Fig4: Immunohistochemical analysis of paraffin-embedded mouse brain tissue using anti-GRK2 antibody. Counter stained with hematoxylin.
Application
Fig5: Immunohistochemical analysis of paraffin-embedded mouse spleen tissue using anti-GRK2 antibody. Counter stained with hematoxylin.| Positive Control | Hela, human tonsil tissue, human spleen tissue, mouse brain tissue, mouse spleen tissue |
|---|---|
| Application Notes | WB:1:1,000-1:2,000 IHC:1:50-1:200 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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