AA408962 antibody AA553318 antibody AI844835 antibody Cphn 2 antibody Cphn2 antibody Cyclophilin B antibody Cyclophilin like protein antibody CyP 20b antibody CYP S1 antibody CYP-S1 antibody CYPB antibody EC 5.2.1.8 antibody MGC14109 antibody MGC2224 antibody OI9 antibody peptidyl prolyl cis trans isomerase B antibody Peptidyl prolyl cis trans isomerase B precursor antibody Peptidyl-prolyl cis-trans isomerase B antibody peptidylprolyl isomerase B (cyclophilin B) antibody Peptidylprolyl isomerase B antibody PPIase antibody PPIase B antibody Ppib antibody PPIB_HUMAN antibody Rotamase antibody Rotamase B antibody S cyclophilin antibody S-cyclophilin antibody SCYLP antibody
Product description
The immunosuppressant cyclosporin A (CsA) forms a trimolecular complex with cyclophilin and calcineurins to inhibit calcineurin phosphatase activity. Cyclophilins are conserved, ubiquitous and abundant cytosolic peptidyl-prolyl cis-trans isomerases that accelerate the isomerization of XaaPro peptide bonds and the refolding of proteins. Human cyclophilin A (CyPA), an intracellular protein of 165 amino acids, is the target of the Cyclosporin A and is encoded by a single unique gene conserved from yeast to humans. CyPA is known for its involvement in T cell differentiation and proliferation and is highly expressed in brain. CyPA is incorporated into the virion of the type 1 human immunodeficiency virus (HIV-1) via a direct interaction with the capsid domain of the viral Gag polyprotein and is crucial for efficient viral replication. Cyclophilin B (CyPB) is a member of the cyclophilin family with specific N- and C-terminal extensions. Unlike CyPA, CyPB has a signal sequence leading to its translocation in the endoplasmic reticulum. CyPB is secreted in biological fluids such as blood or milk and binds to a specific receptor present on the human lymphoblastic cell line Jurkat and on human peripheral blood lymphocytes.
Immunogen
recombinant protein
Key Feature
Clonality
Monoclonal
Isotype
IgG
Host Species
Recombinant rabbit
Tested Applications
WB
WB:1:1,000-1:5,000
Species Reactivity
HumanMouseRat
Concentration
1mg/ml
Target Information
Alternative Names
AA408962 antibody AA553318 antibody AI844835 antibody Cphn 2 antibody Cphn2 antibody Cyclophilin B antibody Cyclophilin like protein antibody CyP 20b antibody CYP S1 antibody CYP-S1 antibody CYPB antibody EC 5.2.1.8 antibody MGC14109 antibody MGC2224 antibody OI9 antibody peptidyl prolyl cis trans isomerase B antibody Peptidyl prolyl cis trans isomerase B precursor antibody Peptidyl-prolyl cis-trans isomerase B antibody peptidylprolyl isomerase B (cyclophilin B) antibody Peptidylprolyl isomerase B antibody PPIase antibody PPIase B antibody Ppib antibody PPIB_HUMAN antibody Rotamase antibody Rotamase B antibody S cyclophilin antibody S-cyclophilin antibody SCYLP antibody
Fig1: Western blot analysis of Cyclophilin B on different lysates using anti-Cyclophilin B antibody at 1/1,000 dilution. Positive control: Lane 1: Hela Lane 2: HepG2 Lane 3: NIH/3T3
Positive Control
NIH/3T3, Hela, HepG2.
Application Notes
WB:1:1,000-1:5,000
Additional Information
Form
Liquid
Storage Instructions
Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
