GATA-3 antibody (GATA binding protein 3) is a member of the GATA family of transcription factors. GATA-3 appears to control a set of genes involved in the differentiation and proliferation of breast cancer. The expression of GATA-3 has a strong association with estrogen receptor-alpha expression in breast cancer and evidence exists that GATA-3 may be used to predict response to hormonal therapy of breast cancer patients. GATA-3 has also been shown to be a novel marker for bladder cancer. In one study, GATA-3 stained 67% of 308 urothelial carcinomas but no prostate or renal carcinomas.
Immunogen
Synthetic phospho-peptide corresponding to residues surrounding Ser308 of human GATA3.
Fig1: Western blot analysis of Phospho-GATA3(S308) on human skin lysates using anti-Phospho-GATA3(S308) antibody at 1/1,000 dilution.
Application
Fig2: Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using anti-Phospho-GATA3(S308) antibody. Counter stained with hematoxylin.
Positive Control
Human skin tissue, human breast carcinoma tissue.
Application Notes
WB:1:1,000-1:2,000 IHC:1:50-1:200
Additional Information
Form
Liquid
Storage Instructions
Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
