| 存储条件 |
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| Product Name | CELF1 [7A1] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | 50 kDa Nuclear polyadenylated RNA binding protein antibody 50 kDa nuclear polyadenylated RNA-binding protein antibody Bruno like 2 antibody bruno like protein 2 antibody Bruno-like protein 2 antibody BRUNOL 2 antibody BRUNOL2 antibody CELF 1 antibody CELF-1 antibody celf1 antibody CELF1 CUGBP, Elav like family member 1 antibody CELF1_HUMAN antibody CUG BP and ETR 3 like factor 1 antibody CUG BP antibody CUG BP1 antibody CUG RNA binding protein antibody CUG triplet repeat RNA binding protein 1 antibody CUG triplet repeat RNA-binding protein 1 antibody CUG-BP antibody CUG-BP- and ETR-3-like factor 1 antibody CUG-BP1 antibody CUGBP 1 antibody CUGBP and ETR3 like factor 1 antibody CUGBP antibody CUGBP Elav like family member 1 antibody CUGBP Elav-like family member 1 antibody CUGBP1 antibody Cytidine uridine guanosine binding protein 1 antibody Deadenylation factor CUG BP antibody Deadenylation factor CUG-BP antibody Deadenylation factor CUGBP antibody EDEN BP antibody EDEN BP homolog antibody EDEN-BP antibody EDEN-BP homolog antibody embryo deadenylation element binding protein antibody embryo deadenylation element binding protein homolog antibody Embryo deadenylation element-binding protein homolog antibody hNab 50 antibody hNab50 antibody NAB 50 antibody NAB50 antibody NAPOR antibody Nuclear polyadenylated RNA binding protein 50 kD antibody Nuclear polyadenylated RNA binding protein antibody RNA binding protein BRUNOL 2 antibody RNA binding protein BRUNOL2 antibody RNA-binding protein BRUNOL-2 antibody |
| Product description | Myotonic dystrophy (DM) is an autosomal dominant neuromuscular disease that is associated with a (CTG)n repeat expansion in the 3'-untranslated region of the myotonin protein kinase gene (DMPK). CUG-BP1 and CUG-BP2 are proteins that bind specifically to (CUG)8 oligonucleotides in vitro. While CUG-BP1 has the major binding activity in normal cells, nuclear CUG-BP2 binding activity increases in DM cells. Both CUG-BP1 and CUG-BP2 are isoforms of a novel heterogeneous nuclear ribonucleoprotein (hnRNP), hNab50. CUG-BP1, an RNA CUG triplet repeat binding protein, regulates splicing and translation of various RNAs. Expansion of RNA CUG repeats in the DMPK in DM is associated with alterations in binding activity of CUG-BP1 as well as alterations in the translation of the C/EBPb transcription factor. CUG-BP1 is an important regulator of initiation from different AUG codons of C/EBPb mRNA. In normal cells, CUG-BP1 up-regulates the p21 protein during differentiation by inducing the translation of p21 via binding to a GC-rich sequence located within the 5' region of p21 mRNA. In DM cells, failure to accumulate CUG-BP1 leads to a reduction of p21 and alterations in other proteins responsible for cell cycle withdrawl. |
| Immunogen | Recombinant protein within human CELF1 aa 1-180. |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Host Species | Mouse |
| Tested Applications | IHCWB |
| IHC:1:50-1:200 WB:1:2,000-1:5,000 | |
| Species Reactivity | Human |
| Concentration | 2mg/ml |
| Alternative Names | 50 kDa Nuclear polyadenylated RNA binding protein antibody 50 kDa nuclear polyadenylated RNA-binding protein antibody Bruno like 2 antibody bruno like protein 2 antibody Bruno-like protein 2 antibody BRUNOL 2 antibody BRUNOL2 antibody CELF 1 antibody CELF-1 antibody celf1 antibody CELF1 CUGBP Elav like family member 1 antibody CELF1_HUMAN antibody CUG BP and ETR 3 like factor 1 antibody CUG BP antibody CUG BP1 antibody CUG RNA binding protein antibody CUG triplet repeat RNA binding protein 1 antibody CUG triplet repeat RNA-binding protein 1 antibody CUG-BP antibody CUG-BP- and ETR-3-like factor 1 antibody CUG-BP1 antibody CUGBP 1 antibody CUGBP and ETR3 like factor 1 antibody CUGBP antibody CUGBP Elav like family member 1 antibody CUGBP Elav-like family member 1 antibody CUGBP1 antibody Cytidine uridine guanosine binding protein 1 antibody Deadenylation factor CUG BP antibody Deadenylation factor CUG-BP antibody Deadenylation factor CUGBP antibody EDEN BP antibody EDEN BP homolog antibody EDEN-BP antibody EDEN-BP homolog antibody embryo deadenylation element binding protein antibody embryo deadenylation element binding protein homolog antibody Embryo deadenylation element-binding protein homolog antibody hNab 50 antibody hNab50 antibody NAB 50 antibody NAB50 antibody NAPOR antibody Nuclear polyadenylated RNA binding protein 50 kD antibody Nuclear polyadenylated RNA binding protein antibody RNA binding protein BRUNOL 2 antibody RNA binding protein BRUNOL2 antibody RNA-binding protein BRUNOL-2 antibody |
|---|---|
| Molecular Weight(MW) | 52 kDa |
| Cellular Localization | Cytoplasm. Nucleus. |
| SwissProt ID | Q92879 |
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Application
Fig1: Western blot analysis of CELF1 on Daudi cell lysate using anti-CELF1 antibody at 1/5,000 dilution.
Application
Fig2: Immunohistochemical analysis of paraffin-embedded human spleen tissue using anti-CELF1 antibody. Counter stained with hematoxylin.
Application
Fig3: Immunohistochemical analysis of paraffin-embedded human pancreas tissue using anti-CELF1 antibody. Counter stained with hematoxylin.
Application
Fig4: Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-CELF1 antibody. Counter stained with hematoxylin.| Positive Control | Human tonsil tissue, human spleen tissue, human pancreas tissue, Daudi. |
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| Application Notes | IHC:1:50-1:200 WB:1:2,000-1:5,000 |
| Form | Liquid |
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| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 0.5%BSA, 50%Glycerol. Preservative: 0.05% Sodium Azide. |
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