| 存储条件 |
|---|
| Product Name | Integrin beta 3 [SJ19-09] |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Integrins are heterodimers composed of noncovalently associated transmembrane a and b subunits. The 16 a and 8 b subunits heterodimerize to produce more than 20 different receptors. Most integrin receptors bind ligands that are components of the extracellular matrix, including Fibronectin, Collagen and Vitronectin. Certain integrins can also bind to soluble ligands such as Fibrinogen, or to counterreceptors on adjacent cells such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. Ligands serve to cross-link or cluster integrins by binding to adjacent integrin receptors; both receptor clustering and ligand occupancy are necessary for the activation of integrin-mediated responses. In addition to mediating cell adhesion and cytoskeletal organization, integrins function as signaling receptors. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis. |
| Immunogen | recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Recombinant rabbit |
| Tested Applications | WB,IHC,ICC/IF |
| WB:1:1,000 ICC:1:50-1:200 IHC:1:50-1:200 | |
| Species Reactivity | Human,Mouse,Rat |
| Concentration | 1mg/ml |
| Purification | Unpurified |
| Alternative Names | BDPLT16 antibody BDPLT2 antibody CD 61 antibody CD61 antibody CD61 antigen antibody GP3A antibody GPIIIa antibody GT antibody HPA 1 antibody HPA 4 antibody Integrin beta 3 (platelet glycoprotein IIIa antigen CD61) antibody Integrin beta chain beta 3 antibody Integrin beta-3 antibody ITB3_HUMAN antibody ITG B3 antibody ITGB 3 antibody ITGB3 antibody NAIT antibody Platelet fibrinogen receptor beta subunit antibody Platelet fibrinogen receptor beta subunit antibody Platelet glycoprotein IIIa antibody Platelet glycoprotein IIIa precursor antibody Platelet membrane glycoprotein IIIa antibody PTP antibody |
|---|---|
| Molecular Weight(MW) | 87 kDa |
| Cellular Localization | Cell membrane, Cell projection, Cell junction. |
Application
Fig1: Western blot analysis of Integrin beta 3 on different lysates using anti- Integrin beta 3 antibody at 1/1,000 dilution. Positive control: Lane 1: HUVEC cells lysate Lane 2: Mouse marrow tissue lysate
Application
Fig2: ICC staining Integrin beta 3 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Application
Fig3: ICC staining Integrin beta 3 in HepG2 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Application
Fig4: Immunohistochemical analysis of paraffin-embedded human spleen tissue using anti-Integrin beta 3 antibody. Counter stained with hematoxylin.
Application
Fig5: Immunohistochemical analysis of paraffin-embedded mouse testis tissue using anti-Integrin beta 3 antibody. Counter stained with hematoxylin.
Application
Fig6: Immunohistochemical analysis of paraffin-embedded human liver cancer tissue using anti-Integrin beta 3 antibody. Counter stained with hematoxylin.
Application
Fig7: Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using anti-Integrin beta 3 antibody. Counter stained with hematoxylin.
Application
Fig8: Immunohistochemical analysis of paraffin-embedded mouse colon tissue using anti-Integrin beta 3 antibody. Counter stained with hematoxylin.| Positive Control | HUVEC, HepG2, Hela, human liver cancer tissue, human spleen tissue, mouse testis tissue, human breast carcinoma tissue, mouse colon tissue. |
|---|---|
| Application Notes | WB:1:1,000 ICC:1:50-1:200 IHC:1:50-1:200 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
抱歉，暂无相关文献
抱歉，暂无浏览记录
