CD20 is a leukocyte surface antigen consisting of four transmembrane regions and cytoplasmic N- and C-termini. The cytoplasmic domain of CD20 contains multiple phosphorylation sites, leading to additional isoforms. CD20 is expressed primarily on B cells but has also been detected on both normal and neoplastic T cells. CD20 functions as a calcium-permeable cation channel, and it is known to accelerate the G0 to G1 progression induced by IGF-1. CD20 is activated by the IGF-1 receptor via the alpha subunits of the heterotrimeric G proteins. Activation of CD20 significantly increases DNA synthesis and is thought to involve basic helix-loop-helix leucine zipper transcription factors.
Immunogen
recombinant protein
Key Feature
Clonality
Monoclonal
Isotype
IgG
Host Species
Recombinant rabbit
Tested Applications
WB,IHC,IP
WB:1:1,000-1:5,000 IHC:1:50-1:200
Species Reactivity
Human,Monkey
Concentration
1mg/ml
Purification
Unpurified
Target Information
Alternative Names
APY antibody ATOPY antibody B lymphocyte antigen CD20 antibody B Lymphocyte Cell Surface Antigen B1 antibody B-lymphocyte antigen CD20 antibody B-lymphocyte cell-surface antigen B1 antibody B-lymphocyte surface antigen B1 antibody B1 antibody Bp 35 antibody Bp35 antibody CD 20 antibody CD20 antibody CD20 antigen antibody CD20 receptor antibody CD20_HUMAN antibody CVID5 antibody Fc epsilon receptor I beta chain antibody Fc Fragment of IgE high affinity I receptor for beta polypeptide antibody FCER1B antibody High affinity immunoglobulin epsilon receptor subunit beta antibody IgE Fc receptor subunit beta antibody IGEL antibody IGER antibody IGHER antibody LEU 16 antibody LEU16 antibody leukocyte surface antigen Leu 16 antibody Leukocyte surface antigen Leu-16 antibody Ly44 antibody Membrane spanning 4 domains A1 antibody Membrane spanning 4 domains subfamily A member 2 antibody Membrane-spanning 4-domains subfamily A member 1 antibody MS4A1 antibody MS4A2 antibody S7 antibody
