ETHA antibody GEFSP7 antibody hNE Na antibody hNE-Na antibody hNENa antibody NE NA antibody NENA antibody Neuroendocrine sodium channel antibody Peripheral sodium channel 1 antibody PN1 antibody Scn9a antibody SCN9A_HUMAN antibody Sodium channel protein type 9 subunit alpha antibody Sodium channel protein type IX subunit alpha antibody Sodium channel voltage gated type IX alpha antibody Sodium channel voltage gated type IX alpha polypeptide antibody Sodium channel voltage gated type IX alpha subunit antibody Voltage gated sodium channel alpha subunit Nav1.7 antibody Voltage gated sodium channel subunit alpha Nav1 antibody Voltage-gated sodium channel subunit alpha Nav1.7 antibody
Product description
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-sensitive Na(+) channel isoform. Plays a role in pain mechanisms, especially in the development of inflammatory pain.
Immunogen
Recombinant protein
Key Feature
Clonality
Monoclonal
Isotype
Ig2b
Host Species
Mouse
Tested Applications
IHCICCFCWB
ICC:1:50-1:200 IHC
Species Reactivity
Human
Concentration
2mg/ml
Target Information
Alternative Names
ETHA antibody GEFSP7 antibody hNE Na antibody hNE-Na antibody hNENa antibody NE NA antibody NENA antibody Neuroendocrine sodium channel antibody Peripheral sodium channel 1 antibody PN1 antibody Scn9a antibody SCN9A_HUMAN antibody Sodium channel protein type 9 subunit alpha antibody Sodium channel protein type IX subunit alpha antibody Sodium channel voltage gated type IX alpha antibody Sodium channel voltage gated type IX alpha polypeptide antibody Sodium channel voltage gated type IX alpha subunit antibody Voltage gated sodium channel alpha subunit Nav1.7 antibody Voltage gated sodium channel subunit alpha Nav1 antibody Voltage-gated sodium channel subunit alpha Nav1.7 antibody
Fig1: ICC staining NaV1.7 (green) in A549 cells. The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Application
Fig2: ICC staining NaV1.7 (green) in Hela cells. The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Application
Fig3: Immunohistochemical analysis of paraffin-embedded human colon cancer tissue using anti-NaV1.7 antibody. Counter stained with hematoxylin.
Application
Fig4: Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-NaV1.7 antibody. Counter stained with hematoxylin.
Application
Fig5: Flow cytometric analysis of A549 cells with NaV1.7 antibody at 1/50 dilution (blue) compared with an unlabelled control (cells without incubation with primary antibody; red). Goat anti mouse IgG (FITC) was used as the secondary antibody.
Positive Control
A549, Hela, human colon cancer tissue, human kidney tissue, A549.
Application Notes
ICC:1:50-1:200 IHC
Additional Information
Form
Liquid
Storage Instructions
Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
