Avian myelocytomatosis viral oncogene homolog antibody bHLHe39 antibody c Myc antibody Class E basic helix-loop-helix protein 39 antibody MRTL antibody Myc antibody Myc protein antibody Myc proto oncogene protein antibody Myc proto-oncogene protein antibody myc related translation/localization regulatory factor antibody MYC_HUMAN antibody Myc2 antibody MYCC antibody Niard antibody Nird antibody Proto-oncogene c-Myc antibody Transcription factor p64 antibody v myc avian myelocytomatosis viral oncogene homolog antibody v myc myelocytomatosis viral oncogene homolog antibody
Product description
c-Myc-, N-Myc- and L-Myc-encoded proteins function in cell proliferation, differentiation and neoplastic disease. Myc proteins are nuclear proteins with relatively short half lives. Amplification of the c-Myc gene has been found in several types of human tumors including lung, breast and colon carcinomas, while the N-Myc gene has been found amplified in neuroblastomas. The L-Myc gene has been reported to be amplified and expressed at high level in human small cell lung carcinomas. The presence of three sequence motifs in the c-Myc COOH terminus, including the leucine zipper, the helix-loop-helix and a basic region provided initial evidence for a sequence-specific binding function. A basic region helix-loop-helix leucine zipper motif (bHLH-Zip) protein, designated Max, specifically associates with c-Myc, N-Myc and L-Myc proteins. The Myc-Max complex binds to DNA in a sequence-specific manner under conditions where neither Max nor Myc exhibit appreciable binding. Max can also form heterodimers with at least two additional bHLH-Zip proteins, Mad and Mxi1, and Mad-Max dimers have been shown to repress transcription through interaction with mSin3.
Immunogen
Synthetic phospho-peptide corresponding to residues surrounding Thr58 and Ser62 of human c-Myc.
Modification
p-T58+S62
Key Feature
Clonality
Monoclonal
Isotype
IgG
Host Species
Recombinant rabbit
Tested Applications
WBICC/IFIP
WB:1:1,000 ICC:1:50-1:200
Species Reactivity
HumanRat
Concentration
1mg/ml
Purification
Unpurified
Target Information
Alternative Names
Avian myelocytomatosis viral oncogene homolog antibody bHLHe39 antibody c Myc antibody Class E basic helix-loop-helix protein 39 antibody MRTL antibody Myc antibody Myc protein antibody Myc proto oncogene protein antibody Myc proto-oncogene protein antibody myc related translation/localization regulatory factor antibody MYC_HUMAN antibody Myc2 antibody MYCC antibody Niard antibody Nird antibody Proto-oncogene c-Myc antibody Transcription factor p64 antibody v myc avian myelocytomatosis viral oncogene homolog antibody v myc myelocytomatosis viral oncogene homolog antibody
