| 存储条件 |
|---|
| Product Name | beta 2 Adrenergic Receptor [JM102-06] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | ADRB2 antibody ADRB2_HUMAN antibody ADRB2R antibody ADRBR antibody Adrenergic beta 2 receptor surface antibody Adrenoceptor beta 2 surface antibody B2AR antibody BAR antibody beta 2 adrenoceptor antibody Beta 2 adrenoreceptor antibody Beta-2 adrenergic receptor antibody Beta-2 adrenoceptor antibody Beta-2 adrenoreceptor antibody BETA2AR antibody Catecholamine receptor antibody OTTHUMP00000160386 antibody |
| Product description | Adrenergic receptors (ARs) (the term "adrenergic" reflects the alternative name for epinephrine, adrenaline) include four general types (a1, a2, b1 and b2) which are found in different target tissues and differ in their affinities and responses to various agonists and antagonists. cDNA clones have been isolated for all of the major AR subtypes and a number of closely related receptors have been identified by this approach. Each of the receptors have been shown to consist of single polypeptide chains which transverse the plasma membrane seven times, presumably forming a bundle of helices within the membrane. These transmembrane regions are hydrophobic and are interconnected by extracellular and intracellular hydrophilic loops. The coupling of ARs to specific intracellular effectors is mediated through diverse heterotrimeric G proteins and is regulated by G protein-coupled receptor kinases (GRKs), cAMP-dependent protein kinase A and protein kinase C directed phosphorylation. b2-adrenergic receptors bind cathecholamines (epinephrine, norepinephrine) and influence development, behavior, cardiac function, smooth muscle tone, and metabolism. b2-AR signaling complexes can contain C L-type calcium channel Ca(V)1.2, G protein, adenylyl cyclase, cAMP-dependent kinase, and PP2A phosphatase. |
| Immunogen | recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Recombinant rabbit |
| Tested Applications | WBIHCIP |
| WB:1:1,000-1:5,000 IHC:1:50-1:200 | |
| Species Reactivity | HumanMouseRatZebra Fish |
| Concentration | 1mg/ml |
| Alternative Names | ADRB2 antibody ADRB2_HUMAN antibody ADRB2R antibody ADRBR antibody Adrenergic beta 2 receptor surface antibody Adrenoceptor beta 2 surface antibody B2AR antibody BAR antibody beta 2 adrenoceptor antibody Beta 2 adrenoreceptor antibody Beta-2 adrenergic receptor antibody Beta-2 adrenoceptor antibody Beta-2 adrenoreceptor antibody BETA2AR antibody Catecholamine receptor antibody OTTHUMP00000160386 antibody |
|---|---|
| Molecular Weight(MW) | 60 kDa |
| Cellular Localization | Cell membrane, Early endosome. |
Application
Fig1: Western blot analysis of ADRB2 on zebrafish lysates using anti-ADRB2 antibody at 1/1,000 dilution.
Application
Fig2: Immunohistochemical analysis of paraffin-embedded mouse liver tissue using anti-ADRB2 antibody. Counter stained with hematoxylin.
Application
Fig3: Immunohistochemical analysis of paraffin-embedded mouse brain tissue using anti-ADRB2 antibody. Counter stained with hematoxylin.| Positive Control | zebrafish, mouse liver tissue, mouse brain tissue. |
|---|---|
| Application Notes | WB:1:1,000-1:5,000 IHC:1:50-1:200 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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