Human 4-1BB Ligand (TNFSF9) Recombinant Protein, PeproTech®

应用

免疫印迹 (WB)

酶联免疫吸附实验 (ELISA)

功能检测 (Functional)

体外检测 (IV)

其他PubMed (Misc)

产品规格

种属：Human

已发表种属：Human, Mouse

Expression System：E. coli

氨基酸序列：MREGPELSPD DPAGLLDLRQ GMFAQLVAQN VLLIDGPLSW YSDPGLAGVS LTGGLSYKED TKELVVAKAG VYYVFFQLEL RRVVAGEGSG SVSLALHLQP LRSAAGAAAL ALTVDLPPAS SEARNSAFGF QGRLLHLSAG QRLGVHLHTE ARARHAWQLT QGATVLGLFR VTPEIPAGLP SPRSE

分子量：19.5 kDa

分类：Recombinant

类型：Protein

纯度：≥ 98% by SDS-PAGE gel and HPLC analyses.

内毒素浓度：<1 EU/µg

活性：Determined by the dose-dependent stimulation of IL-8 production by human PBMC. The ED50 for this effect is 5-10 ng/ml. Please Note: Results may vary with PBMC donors.

偶联物：Unconjugated

形式：Lyophilized

纯化类型：purified

内含物：no preservative

保存条件：-20°C

运输条件：Ambient

产品详细信息

Recombinant Human 4-1BBL is a soluble 19.5 kDa protein consisting of 185 amino acid residues.

This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

靶标信息

CD137 ligand (CD137L) is a type II membrane protein and part of the TNF superfamily. CD137L is a co-stimulatory molecule that is expressed on antigen presenting cells (DCs, monocytes/macrophages, B cells) and is upregulated upon activation. Its receptor, CD137/4-1BB, is found on a variety of cells, including inflamed endothelial cells, where its expression enhances extravasation of CD137L expressing monocytes. Activated T cells also express CD137, and engagement with CD137L enhances T cell proliferation, IL-2 secretion, survival, and cytotoxic activity. CD137L is also expressed on a majority of B-cell lymphomas, including mantle cell lymphoma, follicular lymphoma, and diffuse large B-cell lymphoma (but it is lacking on Hodgkin lymphoma and T-cell lymphoma). CD137L is also expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interactions.

仅用于科研。不用于诊断过程。未经明确授权不得转售。